Medical Professionals Reference (MPR)Wegovy Labeling Updated With Additional Option for Maintenance Dosing

Wegovy is a glucagon-like peptide-1 receptor agonist.

The updated prescribing information for Wegovy (semaglutide) now includes new guidelines for maintenance dosing in adults and pediatric patients. This change is based on a recent study and offers more flexibility in dosing options for adults, while pediatric dosing remains unchanged.

Key Points:

• Wegovy is used for chronic weight management in adults and pediatric patients with specific BMI criteria.
• The maintenance dosage for adults can now be either 2.4mg (recommended) or 1.7mg once weekly.
• The update was informed by a study involving 401 East Asian patients, showing significant weight reduction with both 1.7mg and 2.4mg doses.
• Previously, the labeling required discontinuation in adults unable to tolerate 2.4mg; this has been removed, and 1.7mg has been added as an option.

Additional Points:

• Pediatric maintenance dosage remains at 2.4mg once weekly.
• Treatment response and tolerability are key factors in selecting the maintenance dosage.

Conclusion:

• The updated guidelines provide more flexibility in adult maintenance dosing, reflecting the latest research findings, while pediatric guidelines remain consistent.

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Additional Info
US Food and Drug Administration. Wegovy supplement approval letter.