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GoodRx Health5 Outdated High Blood Pressure Medications You Should Consider Upgrading


Recent guidelines have shifted the landscape of hypertension management, emphasizing the use of four primary medication classes while cautioning against older, potentially outdated options. This article outlines the current recommendations for first-line antihypertensive treatments and highlights medications that may warrant reconsideration in clinical practice.

Key Points:

  • The four recommended first-line antihypertensive medication classes are thiazide diuretics, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and calcium channel blockers (CCBs).
  • Beta-blockers are no longer considered first-choice therapies for hypertension but may be appropriate in specific scenarios such as heart rhythm problems, coronary artery disease, or heart failure.
  • Loop diuretics like furosemide are not first-line for hypertension but remain useful for managing fluid overload in heart failure.
  • Alpha blockers, vasodilators, and alpha-2 agonists are associated with more side effects and are generally not recommended as initial hypertension treatments.
  • Medication choice should be individualized based on patient comorbidities, with regular monitoring for potential side effects and efficacy.

HCN Medical Memo
When managing hypertension, prioritize thiazide diuretics, ACE inhibitors, ARBs, and CCBs as first-line treatments. Reassess patients on older antihypertensive medications, considering potential updates to their regimens based on current guidelines and individual patient factors.


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