In this video, Dr. Robert Vonderheide, the Director of the Abramson Cancer Center at Penn Medicine, discusses cancer interception, an approach to cancer treatment that involves identifying and treating pre-cancerous cells before they develop into tumors. Dr. Vonderheide explains that cancer interception involves using genomic sequencing to identify cells that are at high risk of developing into cancer and then using drugs or other treatments to kill these cells before they become cancerous. He notes that cancer interception has the potential to be a highly effective form of cancer treatment, but that it requires a collaborative approach between researchers, clinicians, and patients. Dr. Vonderheide also discusses the role of immunotherapy in cancer interception and the challenges associated with developing effective interception strategies for different types of cancer.