BloodControlling CNS Relapse in Children with ALL Treated Without Cranial Irradiation

Publication: Blood

Key Points: The authors identified the following four prognostic indicators that could help control CNS relapse in children with ALL. 1) Prephase dexamethasone treatment, 2) delayed intrathecal therapy, 3) use of total intravenous anesthesia during intrathecal therapy, and 4) flow cytometry examination of diagnostic CSF

Design: 7,640 consecutive patients treated on Chinese Children’s Cancer Group ALL-2015 protocol