
A recent report published in BMJ Nutrition, Prevention & Health examines the physiological mechanisms of how carbonated water consumption may influence weight loss through glucose metabolism. The research draws parallels between the metabolic processes triggered by sparkling water consumption and those observed in hemodialysis, specifically focusing on red blood cell glucose uptake and the role of carbonic anhydrase.
Key Points:
- The physiological process begins when CO2 from sparkling water enters the bloodstream through stomach capillaries, where red blood cells convert it to bicarbonate using carbonic anhydrase. This conversion creates an alkaline environment within red blood cells, potentially accelerating glucose breakdown through glycolysis.
- During a four-hour hemodialysis session, approximately 9.5g of glucose is consumed through similar mechanisms. However, the report indicates that sparkling water’s effect on glucose consumption is significantly smaller due to shorter CO2 exposure duration, making its direct impact on weight loss minimal.
- Clinical implications include the potential for temporary blood glucose measurement inaccuracies following carbonated water consumption, as readings may appear artificially lower than actual levels.
- The report acknowledges several limitations, including its basis on single-author research and reliance on a 2004 study. The author recommends future studies using continuous glucose monitoring (CGM) to verify the effects of carbonated water on blood glucose levels.
- Side effects of sparkling water consumption include potential digestive system impacts, bloating, and gas, emphasizing the importance of moderate consumption within a comprehensive weight management approach.

HCN Medical Memo
Although sparkling water consumption may influence glucose metabolism through CO2-mediated changes in red blood cell pH, its effects are temporary and minimal. Consider potential impacts on blood glucose readings when interpreting results from patients who recently consumed carbonated beverages.
Glycemic Control Coverage