JAMA NetworkEfficacy of Benzodiazepines or Antihistamines for Patients With Acute Vertigo: A Systematic Review and Meta-analysis

Seven studies totaling 802 patients investigated the primary outcome of change in 100-point vertigo visual analog scale scores at around 2 hours following treatment with an antihistamine or benzodiazepine in this systematic review and meta-analysis of 1,586 participants within 17 trials. Antihistamines improved patients’ conditions more than benzodiazepines did (difference, 16.1), but they weren’t better than other active comparators such ondansetron, droperidol, metoclopramide, and piracetam.