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Medical Professionals Reference (MPR)Jardiance Approved for Adults with Chronic Kidney Disease

The SGLT2 inhibitor may provide a new hope for chronic kidney disease.

The US Food and Drug Administration (FDA) has given the green light to Jardiance (empagliflozin), a medication designed to mitigate the risk of chronic kidney disease (CKD) progression, end-stage kidney disease, cardiovascular death, and hospitalization in adults. This approval marks a significant step forward in the treatment of CKD, offering a new option for healthcare professionals and hope for patients.

Key Points

  • The FDA approval is based on data from the phase 3 EMPA-KIDNEY trial, which included 6609 adults with CKD.
  • The trial showed that treatment with empagliflozin reduced the risk of kidney disease progression or CV death by 28% compared with placebo.
  • Empagliflozin was also associated with a 14% reduction in the risk of first and recurrent hospitalization compared with placebo.
  • Approximately 44% of the study population had type 2 diabetes.
  • Jardiance is not recommended for the treatment of CKD in patients with polycystic kidney disease or patients requiring or with a recent history of intravenous immunosuppressive therapy.

According to the National Kidney Foundation, approximately 37 million people in the United States have chronic kidney disease, and millions more are at risk.

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