Addiction ProfessionalXylazine Crisis: 6 Things Treatment Providers Should Know

Understanding Xylazine: The Rising Challenge in Opioid Crisis Management

As physicians, it’s crucial to stay informed about emerging drug threats. Xylazine, a powerful livestock tranquilizer mixed into fentanyl, is one such threat that’s gaining momentum.

• Xylazine, a fentanyl add-on, was recently declared an emerging threat by the ONDCP.
• First documented in toxicology reports in 2006, xylazine contributed to over 30% of fatal heroin and/or fentanyl overdoses in Philadelphia in 2019.
• Xylazine is now present in 48 of 50 states, with overdose deaths linked to the drug seeing a significant increase across the country.
• Detection of xylazine is challenging due to the lack of specific lab tests and its covert use mixed into other drugs.
• Xylazine does not respond to naloxone treatment, necessitating additional interventions in cases of overdose.
• Xylazine use in humans leads to severe, necrotic flesh wounds and signs of heavy sedation.
• Physicians can aid in combating this crisis by reporting suspected cases of xylazine use, symptoms, and overdoses to the DEA.