Journal of Neurology, Neurosurgery & PsychiatryBiomarkers in Dementia: Clinical Utility and New Directions

Biomarkers may be used in the dementias to distinguish different aspects of the underlying pathology, detect presymptomatic pathological changes, predict decline or conversion between clinical disease states, and/or monitor disease progression and response to treatment. In this review, the authors discuss the currently available biomarkers, with a particular focus on the three most common neurodegenerative dementias: Alzheimer’s disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB).