Journal of Pharmacy Practice (JPP)Neurologic Examination Facilitated by Reversal of Rocuronium with Sugammadex

The modified gamma-cyclodextrin was effective in reversing rocuronium-induced paralysis.

A study of 11 patients with neurologic injuries found that sugammadex was effective in reversing rocuronium-induced paralysis and facilitating neurologic examination. The study, which was conducted at a single institution, found that most patients (72.7%) had definitive changes in neurologic examination after sugammadex administration. Five patients had neurosurgical interventions offered and performed, with 1 of the patients surviving.

Study Design:

• A retrospective review of patient records was conducted to describe the use of sugammadex after implementation of an institutional guideline.
• The study included patients with neurologic injuries who received rocuronium and then sugammadex to facilitate neurologic examinations.
• Eleven patients were included in the study.
• The most common dose of sugammadex was 4 mg/kg.
• The mean time between rocuronium and sugammadex administration was 73.9 minutes.
• The guideline allowed for a dose range of 2 mg/kg to 16 mg/kg of sugammadex.

Key Findings:

• Most patients (72.7%) had definitive changes in neurologic examination after sugammadex administration.
• Five patients had neurosurgical interventions offered and performed, with one of the patients surviving.

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