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Journal of Clinical PathwaysPegfilgrastim Home Redirection Outcomes: Effectiveness and Timing of Administration in Primary Prophylaxis of Chemotherapy-Induced Neutropenia

Covering 13,493 patients over a two-year period, the research compares home-redirection versus conventional care settings, shedding light on potential improvements in clinical outcomes.

The study conducted with commercial medical claims data from Cigna evaluates the impact of home-redirection programs on pegfilgrastim effectiveness and administration timing in chemotherapy-induced neutropenia (CIN) prophylaxis.

Key Points:

  • Patients Involved: 13,493 patients receiving chemotherapy were analyzed between September 2020 and August 2022.
  • Methodology: Descriptive and chi-square statistics, and logistic regression estimated associations between home redirection and outcomes.
  • Clinical Outcomes: The incidence of neutropenia, fever, pneumonia, and sepsis was 32% less likely in home-redirection patients; 43% reduction in odds of same-day pegfilgrastim administration.
  • Compliance with Guidelines: Findings align with evidence-based US guidelines from ASCO and NCCN on the timing of pegfilgrastim administration.
  • Favorable in Home Setting: Pegfilgrastim can be effectively administered in a home setting, as indicated by 32% lower odds of specific clinical complications.

Additional Points:

  • Historical Context: A shift from hospitals to outpatient centers since the 1980s, with innovative opportunities in home administration.
  • Cigna’s Program Benefits: Minimizing outpatient visits, enhancing convenience, promoting value-based care, and optimizing patient outcomes.
  • Limitations: Lack of representation for Medicare and uninsured US population, uncontrolled variables like race, education, heterogeneity in cancer type, and single home-redirection program.


  • The study emphasizes that Cigna’s pegfilgrastim home-redirection program demonstrates potential for better clinical outcomes, compliance with guidelines, and increased affordability and access, thus addressing the efficacy concerns of home-based administration. Further research is required for widespread adoption.

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Did You Know?
Chemotherapy-induced neutropenia (CIN) is a common side effect affecting up to 65% of patients undergoing intensive chemotherapy treatment.

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