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MDLinxPfizer’s Diabetes Drug Results in Similar Weight Loss Levels as Novo’s Ozempic

Comparing the Competitors: Pfizer’s Danuglipron vs. Novo Nordisk’s Ozempic


A recent mid-stage study has shown promising weight-loss results for Pfizer’s diabetes drug, danuglipron, drawing an interesting comparison with Novo Nordisk’s Ozempic.

Key Points:
  • Pfizer’s diabetes drug, danuglipron, demonstrated weight loss comparable to Novo Nordisk’s Ozempic in a mid-stage study involving type 2 diabetes patients.
  • At its highest dose, danuglipron reduced both blood sugar and body weight after 16 weeks compared to a placebo.
  • The trial involved 411 adults with type 2 diabetes, some of whom received the drug and others a placebo.
  • A 120-milligram dose of danuglipron resulted in an average weight loss of around 4.6 kilograms (approximately 10 pounds) after 16 weeks.
  • Pfizer also has another oral diabetes drug, lotiglipron, in the pipeline, which it may bring to late-stage development.
Additional Points:
  • The news of the drug’s effectiveness boosted Pfizer’s share value by 4.5%.
  • The weight loss treatment market is projected to hit $100 billion by the end of the decade, making it a focus of investor interest.
  • Both danuglipron and Ozempic belong to a class of drugs that imitate the gut hormone glucagon-like peptide-1 (GLP-1), designed to suppress appetite and initially developed for type 2 diabetes treatment.
  • Pfizer believes that an oral therapy could be more appealing to patients wanting to avoid injections.
Related Link:

“Pfizer’s danuglipron, when given twice a day, lowered blood sugar in patients at all doses and reduced body weight at the highest dose after 16 weeks compared to placebo.”

Published data by Pfizer Inc.
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