Epoch HealthResearchers Discover New Mechanism Linking Diet and Cancer Risk

New research uncovers how methylglyoxal, a glucose metabolite, can temporarily inhibit the tumor-suppressing BRCA2 protein, linking poor diet and uncontrolled blood sugar to increased cancer risk.

A recent study from the National University of Singapore has revealed a new mechanism by which poor diet and uncontrolled blood sugar can elevate cancer risk. The research shows that methylglyoxal (MGO), a metabolite released during glucose metabolism, can temporarily deactivate the BRCA2 protein, a key player in DNA repair and tumor suppression.

Key Points:

• MGO and BRCA2 Protein: Methylglyoxal (MGO), a glucose metabolite, can temporarily destroy the BRCA2 protein, reducing its levels in cells and inhibiting its tumor-preventing ability.
• Diet and Cancer Risk: Poor diet and uncontrolled blood sugar are linked to an increased risk of cancer due to the effects of MGO on BRCA2.
• BRCA2 Gene Function: BRCA2 repairs DNA and suppresses tumor growth; damage to this gene increases cancer risk.
• MGO Levels: Elevated MGO levels, which are higher in individuals with poor diets, obesity, or diabetes, can contribute to cancer development.
• Early Detection: Routine HbA1C blood tests, typically used for diagnosing diabetes, can help detect elevated MGO levels, offering early warning signs for cancer risk.
• Dietary Interventions: Reducing sugar intake and adopting diets such as Mediterranean or ketogenic can help lower MGO levels and potentially mitigate cancer risk.

“Our study now unearthed a clue that may explain the connection between cancer risk and diet, as well as common diseases like diabetes, which arise from poor diets.”
– Li Ren Kong, Senior Research Fellow, University of Singapore

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