Articles related to MYELOMA

The MajesTEC-1 trial, a phase 1/2 open-label research that revealed effectiveness data from 110 patients with relapsed or refractory multiple myeloma, provided evidence from strong response rates that served as the foundation for the approval. The accelerated approval of a bispecific antibody for the incurable blood malignancy is a first of its kind in the US. Proteasome inhibitor, immunomodulatory drug, and anti-CD38 monoclonal antibody must have been used in prior therapy.

In this phase 1-2 study, patients with triple-class-exposed relapsed or refractory multiple myeloma experienced a high proportion of profound and long-lasting responses to teclistamab. Infections and cytopenias were frequent, and most grade 1 or 2 toxicities were consistent with T-cell misdirection.

A 0.25-credit, 15-minute video CME program that asks the question, “How do you decide which multiple myeloma treatment regimen is best?” Hear what the presenters have to say.

The future certainly looks bright for patients diagnosed with multiple myeloma, as this opinion piece points out, thanks to combination therapies partnered with easily available, reliable minimal residual disease (MRD) assays. How close are we to a functional cure?

Dr. Mohyudding summarizes key findings ASCO reports, including updates on teclistamab in CAR-T, the DETERMINATION trial assessing auto-transplantation, cilta-cel (covered by HCN here), and the ATLAS study evaluating carfilzomib with lenalidomide and dexamethasone as maintenance vs. lenalidomide alone.

This report provides longer-term results from the CARTITUDE-1 trial of ciltacabtagene autoleucel (cilta-cel) in heavily pretreated patients with relapsed/refractory multiple myeloma. This update covers 97 patients at a median follow up of ~28 months. The overall response rate was 97.9%, with an 82% stringent complete response across both standard and high-risk subgroups. These longer-term data from CARTITUDE-1 in triple-class exposed patients with RRMM demonstrate deep and durable responses to cilta-cel over time, including in high-risk subgroups.