Articles related to OVARIAN CANCER

Researchers at Roswell Park Comprehensive Cancer Center have unveiled a novel approach using bispecific T-cell engagers (BiTEs) to enhance immune responses against ovarian cancer. This promising pathway may lead to improved therapeutic options for patients unresponsive to conventional immunotherapies.

Pfizer is lagging behind its peers with Ibrance, but the pharma giant is attempting to unveil the potential of CDK2 inhibitors to overcome CDK4/6 resistance. At the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting, Pfizer and Blueprint gave presentations on posters about their respective agents, and Incyte, Cyclacel, and a few private biotechs also had clinical trials going on. Although there are some positive signs, the research is still in its very early stages, and it is not apparent whether CDK2 inhibition is a workable monotherapy method.

The study followed nearly 143,000 women who underwent hysterectomy for a benign condition over a 20-year-period and compared outcomes between those who had bilateral salpingo-oophorectomy (BSO) and those who didn’t. Younger (under age 45) women who had BSO had a higher 10-year cumulative risk of hospitalization for CVD. Women aged 45 to 54 with BSO had a higher 10-year risk for developing cancer. Based on the findings, the authors suggest a cautious approach to ovarian removal in postmenopausal women and recommend preserving ovaries in premenopausal women without a high risk for ovarian cancer.

Researchers examined the OTC drug shopping patterns of 153 women before being diagnosed with ovarian cancer and compared them to the patterns seen in 120 women without ovarian cancer. Participants in the study also answered questions regarding the symptoms they had and the number of times they had seen their general practitioner in the year preceding a cancer referral or diagnosis. Eight months before diagnosis, there was a substantial difference in the OTC drug buying habits of women with and without ovarian cancer. Up to nine months prior to diagnosis, there was a rise in the purchasing of dyspepsia medications.

In this on-demand webinar, a trio of Roswell Park Comprehensive Cancer Center experts share their wisdom on ovarian, cervical, and endometrial cancers. Dr. Emese Zsiros, Chair of Gynecologic Oncology, hosts the event with presenters Drs. Karen McLean and Katherine LaVinge Mager, Associate Professor of Oncology and Assistant Professor of Oncology in the Department of Gynecologic Oncology, respectively.

This update is based on the results from the June 2022 ATHENA-MONO2 phase III multinational, double-blind, randomized controlled trial (RCT), which showed a significant improvement in progression-free survival (PFS) in patients with stage III-IV epithelial ovarian cancer (EOC) who are in complete or partial response to first-line platinum-based chemotherapy.