Articles related to STEM CELLS

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This article reviews the novel CXCR4 inhibitor motixafortide and its use in hematopoietic stem-cell mobilization. We present a history of stem-cell mobilization and update of recent innovations in novel mobilization strategies. Hematopoietic stem-cell mobilization is a crucial step in autologous stem-cell transplantation. Motixafortide is a novel CXCR4 inhibitor that has been shown in preclinical and clinical trials to mobilize hematopoietic stem cells (HSCs) for transplantation. The drug has extended in vivo activity (>48 h) and high affinity (Ki, 0.32 nM). In a phase 1, two-part study, motixafortide administered to healthy subjects was safe, well tolerated, and led to a rapid and robust increase in the number of circulating HSCs. Motixafortide has been evaluated in a randomized phase 3 trial for autologous transplantation in multiple myeloma. The study showed that the combination of motixafortide and granulocyte colony-stimulating factor (G-CSF) was superior to G-CSF alone in terms of the number of CD34+ cells collected and the time to engraftment. The drug has also been evaluated in combination with plerixafor, another CXCR4 inhibitor, in a phase 1/2 study for autologous transplantation in multiple myeloma. The study showed that the combination of motixafortide and plerixafor was safe and effective in mobilizing HSCs. Motixafortide has […]

An essential component of successfully enhancing transplant outcomes is early viral infection prevention. Clinically severe viral infections have been successfully avoided in hematopoietic cell transplant patients with prophylactic and preventive therapy with antiviral medications. Through a better understanding of the biology and risk factors, the introduction of novel antiviral agents, and developments in immunotherapy, significant progress has been made in the past few decades in preventing viral infections. There is solid proof that herpes simplex virus, varicella-zoster virus, and CMV infection and illness can be prevented. There is a dearth of information on how to effectively prevent infections with human herpesvirus 6, Epstein-Barr virus, adenovirus, and BK virus.