Neurology AdvisorTime Spent in Systolic BP Range an Independent Predictor for Probable Dementia

Could maintaining a consistent blood pressure range be a groundbreaking strategy in dementia prevention?

A recent post hoc analysis has presented novel findings suggesting a significant relationship between systolic blood pressure (SBP) time in target range (TTR) and dementia risk. This correlation is suggested to be independent of mean SBP.

Key Points:

• SBP TTR has been identified as an independent predictor for probable dementia.
• Data from the SPRINT MIND study, involving 8,298 patients, was used for this analysis.
• Patients were divided into three groups based on TTR. Differences in age, gender, race, BMI, history of cardiovascular disease, and assignment to intensive SBP target group were observed among these groups.
• The overall incidence rate of probable dementia was 0.77 per 100 person-years, mild cognitive impairment was 1.63 per 100 person-years, and probable dementia or MCI was 2.18 per 100 person-years.
• SBP TTR associated with lower risk for probable dementia (aHR, 0.86; 95% CI, 0.76-0.98; P =.023) when fully adjusted.

Additional Points:

• Higher rates of probable dementia were observed in individuals with less time in range.
• Stratification by TTR indicated lower risk for dementia with increasing time in range.
• SBP TTR didn’t show significant trends in risk for MCI or probable dementia or MCI.
• Limitations of the study include its post hoc design and exclusion of patients with prior stroke or diabetes, limiting generalizability.

Conclusion:

• This analysis suggests that SBP TTR might be a significant, independent predictor for probable dementia, highlighting the potential benefits of maintaining consistent blood pressure within 110-140 mmHg for dementia prevention.

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Did You Know?
As per the World Health Organization, around 50 million people have dementia globally, with nearly 10 million new cases every year.