The New England Journal of MedicineTriple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial

The trial was a phase 2, double-blind, randomized, placebo-controlled study including adults with a BMI of 30 or higher, or 27 to less than 30 with at least one weight-related condition.

The latest findings from a phase 2 trial offer promising results for the use of retatrutide, a tri-agonist, in the management of obesity. This study has shed light on its dose-response relationships, efficacy, safety, and associated side effects.

Key Points:

• Participants received various doses of retatrutide or placebo once weekly for 48 weeks.
• The primary end point was the percentage change in body weight from baseline to 24 weeks, secondary end points included changes at 48 weeks and reductions of 5% or more, 10% or more, or 15% or more.
• At 48 weeks, the least-squares mean percentage change in body weight in the retatrutide groups was between -8.7% (1-mg group) and -24.2% (12-mg group), compared to -2.1% in the placebo group.

Additional Points:

• At 48 weeks, weight reductions of 5% or more, 10% or more, and 15% or more occurred in 92%, 75%, and 60%, respectively, of participants receiving 4 mg of retatrutide, and up to 100%, 93%, and 83% of those receiving 12 mg.
• The most common adverse events were gastrointestinal and were partially mitigated with a lower starting dose. Dose-dependent increases in heart rate peaked at 24 weeks and declined thereafter.

Conclusion:

• Retatrutide treatment for 48 weeks resulted in substantial reductions in body weight among adults with obesity, suggesting its potential as a new therapeutic option.

Endocrinology Latest Posts

• 9 Health Benefits of CashewsNovember 21, 2024
• Once-Weekly Semaglutide in Persons with Obesity and Knee OsteoarthritisNovember 21, 2024
• Off-brand Ozempic Leaves 10 Dead, 100 HospitalizedNovember 20, 2024
• Comparative Effectiveness and Safety of Atorvastatin Versus Rosuvastatin: A Multi-database Cohort StudyNovember 11, 2024

Did You Know?
As per the World Health Organization, in 2016, more than 1.9 billion adults were overweight, and of these, over 650 million were obese.