A Clinical Puzzle of Unilateral Pleural Effusion in Hodgkin Lymphoma
A 22-year-old medical student’s gradual onset of dyspnea led to the discovery of a unilateral pleural effusion, which upon thorough investigation, was diagnosed as symptomatic of classic Hodgkin lymphoma. The necessity for a systematic approach to pleural effusion evaluation, using both diagnostic and therapeutic procedures to establish and manage underlying malignancies efficiently, is paramount.
Key Points:
- Patient Presentation: A 22-year-old woman with a history of iron deficiency anemia and gastroesophageal reflux disease presented with progressive dyspnea, fatigue, weight loss, night sweats, and palpitations, initially mistaken for stress-related symptoms.
- Initial Assessments: Vital signs showed tachycardia, fever, and reduced oxygen saturation; physical examination revealed pallor, reduced breath sounds in the right hemithorax, and bilateral axillary lymphadenopathy.
- Laboratory Findings: Elevated white blood cell count and C-reactive protein levels suggested an inflammatory process, with normal liver and renal function.
- Imaging Results: Chest radiography and CT scans revealed unilateral right pleural effusion, bulky mediastinal masses, and bilateral axillary lymphadenopathy, indicative of significant thoracic pathology.
- Diagnostic Procedures: Thoracentesis extracted green-hued, lymphocytic, exudative pleural fluid, which lacked infectious agents, pointing towards a non-infectious etiology.
- Cytopathology Results: Analysis of pleural fluid showed atypical lymphocytes, raising suspicions of a hematopoietic malignancy.
- Biopsy Confirmation: Excisional lymph node biopsy confirmed the diagnosis of lymphocyte-rich Hodgkin lymphoma, characterized by distinctive Reed-Sternberg cells.
- Advanced Staging: PET scans diagnosed the patient with stage IV classic Hodgkin lymphoma due to extensive nodal involvement above and below the diaphragm and extranodal involvement.
- Treatment Approach: Initiation of a chemotherapy regimen including doxorubicin, vinblastine, dacarbazine, and brentuximab, which led to symptom resolution and discharge with outpatient follow-up.
- Pleural Effusion Insights: Pleural effusions in Hodgkin lymphoma typically present as exudative and lymphocytic, with a range of appearances from serous to bloody, highlighting the diverse manifestations of lymphomas.
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“The excisional lymph node biopsy, while invasive, remains the gold standard for diagnosing lymphomas, as it allows for a comprehensive examination of the lymph node architecture.”
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