ACP InternistACP’s Updated Depression Guideline Recommends CBT, Second-generation Antidepressants

The updated guidelines recommend, in brief:

• Either cognitive behavioral therapy (CBT) or second-generation antidepressants (SGAs) as first-line monotherapy in the acute phase
• Combination of both therapies in the acute phase as a third choice
• CBT monotherapy in the acute phase of mild MDD
• In non-responding patients on SGAs, add or change to CBT, change SGA, or add a second drug