Psoriasis manifests as more than a dermatological condition, presenting systemic inflammatory effects that can lead to multiple comorbidities. The condition correlates with increased risks of cardiovascular disease, type 2 diabetes, metabolic syndrome, liver disease, psoriatic arthritis, sleep disorders, and mental health conditions. Understanding these associations enables physicians to implement comprehensive management strategies.
Key Points:
- Cardiovascular Impact: Systemic inflammation contributes to arterial plaque buildup and increased mortality from heart disease. The inflammatory cascade affects blood vessel integrity, necessitating cardiovascular risk monitoring in psoriasis patients.
- Metabolic Complications: Patients show higher incidence of type 2 diabetes and metabolic syndrome. Research indicates psoriasis-induced insulin resistance, with risk elevation correlating to symptom severity.
- Hepatic Manifestations: Nonalcoholic fatty liver disease (NAFLD) presents a significant comorbidity, potentially progressing to fibrosis and cirrhosis. Regular liver function monitoring becomes crucial for these patients.
- Joint Involvement: 20-30% of psoriasis patients develop psoriatic arthritis (PsA), causing joint inflammation, deformity, and reduced mobility. Early detection and intervention are essential for preventing permanent joint damage.
- Secondary Health Effects: Sleep disorders (insomnia, sleep apnea) and mental health conditions frequently co-occur, requiring integrated management approaches. These conditions can significantly impact treatment adherence and outcomes.
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HCN Medical Memo
Comprehensive psoriasis management requires regular screening for associated comorbidities, particularly cardiovascular and metabolic conditions. Early intervention and lifestyle modification strategies may help mitigate long-term health risks.
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