Sharecare7 Long-term Health Effects of Psoriasis

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Psoriasis manifests as more than a dermatological condition, presenting systemic inflammatory effects that can lead to multiple comorbidities. The condition correlates with increased risks of cardiovascular disease, type 2 diabetes, metabolic syndrome, liver disease, psoriatic arthritis, sleep disorders, and mental health conditions. Understanding these associations enables physicians to implement comprehensive management strategies.

Key Points:

• Cardiovascular Impact: Systemic inflammation contributes to arterial plaque buildup and increased mortality from heart disease. The inflammatory cascade affects blood vessel integrity, necessitating cardiovascular risk monitoring in psoriasis patients.
• Metabolic Complications: Patients show higher incidence of type 2 diabetes and metabolic syndrome. Research indicates psoriasis-induced insulin resistance, with risk elevation correlating to symptom severity.
• Hepatic Manifestations: Nonalcoholic fatty liver disease (NAFLD) presents a significant comorbidity, potentially progressing to fibrosis and cirrhosis. Regular liver function monitoring becomes crucial for these patients.
• Joint Involvement: 20-30% of psoriasis patients develop psoriatic arthritis (PsA), causing joint inflammation, deformity, and reduced mobility. Early detection and intervention are essential for preventing permanent joint damage.
• Secondary Health Effects: Sleep disorders (insomnia, sleep apnea) and mental health conditions frequently co-occur, requiring integrated management approaches. These conditions can significantly impact treatment adherence and outcomes.

HCN Medical Memo
Comprehensive psoriasis management requires regular screening for associated comorbidities, particularly cardiovascular and metabolic conditions. Early intervention and lifestyle modification strategies may help mitigate long-term health risks.

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