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Psychiatrist.comAntihypertensive Medications and PTSD Incidence in a Trauma Cohort

The study included more than 1.4 million persons who experienced a traumatic event between 1994 and 2016 in Denmark.

In a comprehensive examination of the relationship between antihypertensive medications and PTSD incidence, researchers conducted a 22-year national population-based cohort study in Denmark. The study focused on four classes of antihypertensive drugs and their potential role in PTSD prevention, given the known associations between PTSD and cardiovascular disease. The findings present a nuanced view of the effectiveness of these medications in reducing PTSD incidence.

Study Design:

  • Objective: Assess the association of four classes of antihypertensive drugs with decreased PTSD incidence.
  • Methods: National population-based cohort study using Danish national registries.
  • Data: Incidence rate of PTSD per 100,000 person-years among persons who filled a prescription for beta blockers, ARBs, ACE inhibitors, or calcium channel blockers within 60 days prior to a traumatic event.

Key Findings:

  • Calcium channel blockers were associated with a decreased incidence of PTSD (adjusted hazard ratio = 0.63, 95% CI = 0.34, 1.2).
  • Other antihypertensive medication classes had null or near null associations.


  • The study lays groundwork for further research on antihypertensive medications that may be effective in reducing PTSD incidence and calls for additional replication to clarify inconsistent findings in existing literature.

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Did You Know?
Individuals with PTSD are at a significantly higher risk of developing cardiovascular disease, with some studies showing that PTSD sufferers may have up to a 50% greater risk of heart disease compared to those without PTSD.

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