HealthMedications and Supplements Not To Take With Turmeric

Turmeric, containing the active ingredient curcumin, demonstrates significant potential for drug interactions across multiple medication classes. Although valued for its anti-inflammatory and antioxidant properties, healthcare providers should carefully evaluate its use alongside common prescriptions, particularly those affecting blood coagulation, glucose regulation, and hepatic function.

Key Points:

• Ten medications show notable interactions with turmeric: cancer medications (chemotherapy), blood thinners, blood sugar-lowering agents, amlodipine, estrogen, tamoxifen, hepatotoxic medications, sulfasalazine, tacrolimus, and losartan
• Critical supplement interactions occur with iron supplements, blood-clotting supplements, hepatotoxic supplements, and blood sugar-lowering supplements
• Curcumin doses of 250-1,800mg daily have been associated with liver damage, presenting as hepatitis, cholestasis, or cellular injury
• Animal studies indicate turmeric may increase amlodipine levels significantly in the body, though human studies are pending
• Research shows turmeric binds to estrogen receptors, potentially reducing the effectiveness of hormone replacement therapy

HCN Medical Memo
Clinical vigilance is warranted when patients combine turmeric supplements with prescription medications, particularly those metabolized through hepatic pathways or affecting coagulation and glucose homeostasis.

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