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OBR OncologyNewly Defined High-Risk MCL Subgroup Has “Dismal” Outcomes

Improved personalizing of MCL and addressing unmet needs for those at the highest risk could result from new data that is concentrated on standardizing and clearly identifying patients at high risk for progression and death.

The identification and treatment of high-risk mantle cell lymphoma (MCL) patients have been a challenge in the medical field. A recent study has shed light on a new strategy that combines the Mantle Cell Lymphoma International Prognostic Index (MIPI-c) with p53 overexpression, defining a particularly high-risk group with poor outcomes. This approach may pave the way for personalized treatment plans and the development of innovative therapies targeted to this population.

Key Points:

  • MCL is a rare and incurable subtype of non-Hodgkin lymphoma.
  • The MIPI scoring system has evolved over time, with MIPI-c being the latest development.
  • The study analyzed 1,183 patients, with 22% of cases identified as high-risk (high MIPI-c or p53 expression >50%).
  • High-risk MCL patients had significantly shorter failure-free survival (1.1 years vs 5.6 years) and overall survival (2.2 years vs 13.2 years).

Additional Points:

  • The combination of MIPI-c and p53 overexpression defines a very high-risk group.
  • This identification strategy may lead to aggressive treatment and incorporation of new therapies.
  • It may also prevent overtreating patients who respond well to available therapies.


  • The integration of MIPI index with biological risk factors like TP53 mutation and high Ki-67 expression provides a reliable method to identify a subset of MCL patients with a dismal prognosis, allowing for better risk stratification and the development of innovative therapies for those in greatest need.

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“What we learned here that was new was the p53 by IHC can identify high risk and that the combination of p53 overexpression by IHC plus MIPI-c can define a very high risk group.”

Dr. Brad Kahl
Washington University School of Medicine
St. Louis, MO
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