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Cleveland Clinic Journal of MedicineQuetiapine for Primary Insomnia: Consider the Risks

To sum up the reasons you should use caution:

  • Quetiapine has a variety of effects, including sedation, influencing a number of central nervous system receptors.
  • Quetiapine should only be used to treat insomnia in patients who also have co-occurring mood or schizophrenia spectrum disorders.
  • Quetiapine is less frequently linked to extrapyramidal side effects and dystonia than many other antipsychotic medications, but it is more frequently linked to weight gain, metabolic syndrome, and QTc prolongation.
  • Prior to beginning treatment and then on a frequent basis thereafter, measurements of body mass index, weight, blood pressure, fasting glucose, and lipid levels should be made, even at modest doses.
  • Despite not producing euphoria, quetiapine is frequently misused to amplify or lessen the negative effects of illegal substances.
  • For older patients, quetiapine has additional dangers.
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