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The Journal of Clinical Investigation (JCI)Reversal of Viral and Epigenetic HLA Class I Repression in Merkel Cell Carcinoma (MCC)

Reversal of HLA-I loss is crucial for an effective antitumor cytotoxic T cell response. Thus, HLA-I–upregulating drugs could augment immunotherapy response. The authors describe here a small-molecule USP7 inhibitor as a promising avenue for pharmacologic upregulation of HLA-I in MCC.

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