Roswell ParkRoswell Park Study is First to Show That Exercise Strengthens Immune System in Multiple Myeloma Patients

The study focused on CD4+ and CD8+ T cells, essential for fighting cancer.

A clinical trial led by Roswell Park Comprehensive Cancer Center has revealed that exercise may play a vital role in strengthening the immune system of patients with multiple myeloma. This nonpharmaceutical approach could offer a new way to help control this type of blood cancer, providing hope for a more holistic treatment strategy.

Key Points:

• Forty-three (43) patients participated in a six-month exercise program, with half receiving supervised strength training and the other half using activity trackers.
• The ratio of exhausted to non-exhausted T cells was significantly reduced after the exercise regimen.
• Specifically, the ratio of CD4+ TIGIT+ to non-exhausted CD4+ cells was reduced from 0.71 to 0.57, and CD8+ PD-1+ to non-exhausted CD8+ cells from 1.81 to 1.48.

Additional Points:

• The research was presented at the American Society of Clinical Oncology (ASCO) Annual Meeting.
• A larger prospective trial is being planned to further explore the effects of exercise on immune function, bone disease, and microbiome in patients with monoclonal plasma cell disorders.

Conclusion:

• The study’s findings suggest that exercise could be a promising nonpharmaceutical intervention for multiple myeloma patients, potentially leading to a less-exhausted immune system capable of combating the disease more effectively.

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