Articles related to CLINICAL RESEARCH

Prior research has revealed a potential link between damage to specific parts of the brain and repetitive addictive behaviors. In this report, with findings published in Nature Medicine, the investigators found that lesions that disrupted smoking and alcohol addiction behaviors occurred in many different brain locations and were characterized by a specific pattern of brain connectivity.

The researchers put a theory to the test by administering the compound CBL0137 to melanoma mouse models. This compound causes the same type of highly inflammatory cell death that the influenza virus causes, but it does so directly in cancerous tissue. The resulting antiviral response alerted the immune system. It heated up a “cold” tumor so that, when combined with immunotherapy, the host immune system recognized cancer as something to be destroyed.