Articles related to COVID-19

The inaugural report of the ASH Research Collaborative (RC) COVID-19 Registry for Hematology, published in Blood Advances, is based on an analysis of the first 250 patients with both hematologic malignancy and COVID-19 registered from 74 countries. The analysis showed that the mortality risk (28% overall and increased to 42% among hospitalized patients with COVID-19) was heterogenous and unpredictable, further challenging doctors when allocating resources and determining which patients receive intensive care.

The two new studies in the Morbidity and Mortality Report compared data from July and August 2021 – when delta was dominant to the earlier period in the pandemic – and found that about 1.4 of every 100,000 children/adolescents were hospitalized for COVID-19, nearly 5x the weekly rate in late June and close to the peak in January. Also, the weekly rate of 1.9 per 100,000 children ages 0-4 years in mid-August was nearly 10 times that of late June.

Publication: JAMAMethod: Electronic health record (EHR) data from 8 health systems over seven 4-week surveillance periods to identify and assign gestational ages for spontaneous abortions and ongoing pregnancies; analyzed and compared odds of receiving a COVID-19 vaccine in the 28 days prior to spontaneous abortion and ongoing pregnancies.Results: Of 105,446 unique pregnancies, 13,160 spontaneous abortions and 92,286 ongoing pregnancies were identified; spontaneous abortions did not have an increased odds of exposure to a COVID-19 vaccination in the prior 28 days compared with ongoing pregnancies.

As the influenza season will coincide with the ongoing COVID-19 pandemic, it’s perfect timing for the release of the CDC Advisory Committee on Immunization Practices (ACIP) influenza vaccination updated guidance. The comprehensive report indicates that COVID-19 vaccines can be co-administered with other vaccines, including influenza vaccines like egg-based flu vaccines and cell culture-based inactivated and recombinant vaccines.

Shawna McCafferty, MD, a US Navy Veteran and a pediatrician in Charleston, South Carolina, provides a glimpse into her role as a “terrified and angry” doctor and mother seeing kids suffer from this latest wave and ultimately asking the question, “…exactly how much child death and devastation is acceptable?”  

Publication: Blood AdvancesStudy Design: Prospective study with unmatched health care workforce control group, receiving either Moderna or Pfizer COVID vaccination.Study Population: 23 patients with CLL (61%), lymphoma (39%) (including DLBCL), MCL (13%) and 4% with less common lymphomas.Outcome: Lymphoma patients had significantly lower anti-S IgG titers 28 days post-vaccination compared with controls. Related Article: Efficacy of the BNT162b2 mRNA COVID-19 Vaccine in Patients with B-Cell Non-Hodgkin Lymphoma