Peer-influenced content. Sources you trust. No registration required. This is HCN.
Annals of Internal Medicine
Medical records of more than half a million individuals in the EU, UK, and US were evaluated. Apixaban was the most frequently prescribed direct oral anticoagulant (DOAC) for AFib. It was also associated with a lower incidence of GI bleed vs. the other DOACs.
Cardiology November 9th 2022
JAMA Network
The 100-μg dose of the ERBB2 ICD plasmid-based vaccine was associated with the generation of ERBB2-specific type 1 T cells in the majority of patients with ERBB2-expressing breast cancer in this phase 1 nonrandomized clinical trial, and it is currently being assessed in randomized phase 2 trials.
Oncology, Medical November 7th 2022
In this meta-analysis including 340 patients across six clinical trials, ECT was more effective than ketamine in treating depression. There were no identified differences between the groups in terms of cognition, memory, or serious adverse events.
Neurology October 25th 2022
MDLinx
In this study involving 452 patients with diagnoses of MDD, GAD, and PTSD, IM ketamine reduced depression by 38% and anxiety by 50%, with persistence over 7 months of maintenance therapy.
Family Medicine/General Practice October 20th 2022
Medical Professionals Reference (MPR)
The US Food and Drug Administration (FDA) has said “no” to Akebia Therapeutics’ drug application for vadadustat, a therapy to treat anemia due to chronic kidney disease. Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor designed to mimic the physiologic effect of altitude on oxygen availability. The FDA cited safety concerns as the main reason for it rejecting the application.
Family Medicine/General Practice April 12th 2022
British Medical Journal
Two large scale studies featured in The British Medical Journal concluded that mRNA-based vaccines do not appear to be associated with an increased risk of neurological adverse events; and secondly, that risks of Guillain-Barré syndrome and Bell’s palsy are slightly increased after immunization. Overall, the findings of both studies are reassuring about the safety of the vaccines, particularly compared with the observed risks associated with SARS-CoV-2 infection.
Neurology March 29th 2022