CME 
JOBS 
OUTBREAKS 
PEER-TO-PEER 
QUIZZES & QUESTIONS 
MEDTECH The discovery sheds new light on its potential role in the management of a disease that affects roughly half of all advanced or recurrent endometrial cancer patients.
Maintenance therapy with selinexor, an oral exportin 1 (XPO1) inhibitor, has been found to substantially extend progression-free survival (PFS) in patients with wild-type TP53 advanced or recurrent endometrial cancer. A subset analysis of the phase 3 SIENDO trial, presented at the July 2023 session of ASCO, shows a dramatic improvement in median PFS in a specific group of patients.
Key Points:
- SIENDO trial evaluated selinexor vs. placebo in 263 patients with advanced or recurrent endometrial cancer in remission.
- Median PFS was 27.4 months with selinexor vs. 5.2 months with placebo in wild-type TP53 patients, at a median follow-up of 25.3 months.
- Most common adverse events include nausea, vomiting, diarrhea; grade 3 or higher included neutropenia, nausea, thrombocytopenia.
- Selinexor has FDA approval for relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma but is investigational for endometrial cancer.
Additional Points:
- The new data is described as “unprecedented” and provides a plausible biological hypothesis for this subset benefit.
- A new phase 3 trial (XPORT-EC-042) is underway, focusing on p53 wild-type advanced or recurrent endometrial cancer with 220 participants targeted.
Conclusion:
- The significant PFS benefit with selinexor opens a promising avenue in treating wild-type TP53 endometrial cancer, with ongoing research to confirm and explore these remarkable findings.
OBGYN Latest Posts
- Emergency C-section Leads to $34 Million Award in Malpractice Suit
- Pharmacists’ Experiences Dispensing Misoprostol and Readiness to Dispense Mifepristone
- Risk for Congenital Anomalies in Children Conceived with Medically Assisted Fertility Treatment: A Population-Based Cohort Study
- Stellate Ganglion Block as a Treatment for Vasomotor Symptoms: Clinical Application
“The PFS benefit for selinexor in the p53 wild-type population is unprecedented. There’s a plausible biological hypothesis for this subset benefit.”
Gini Fleming, MD
Discussant for the ASCO Session
Medical Director of Gynecologic Oncology
University of Chicago Medicine
