Journal of Neurology, Neurosurgery & PsychiatryVitamin D Affects the Risk of Disease Activity in Multiple Sclerosis

Vitamin D’s Role in MS: From Genetics to Disease Activity

This study investigates the relationship between vitamin D levels, genetic predisposition to higher vitamin D levels, and disease activity in multiple sclerosis (MS) patients. The research provides insights into how vitamin D may affect MS progression and treatment outcomes.

Study Design:

• 230 untreated relapsing-remitting MS patients had serum 25-OH-vitamin-D measured
• 1408 independent MS patients were analyzed for genetic predisposition to higher vitamin D levels
• Two-sample Mendelian randomisation was used to assess causality

Key Findings:

• Lower baseline vitamin D levels were associated with decreased probability of No Evidence of Disease Activity-3 (NEDA-3) status at 2 years
• Vitamin D levels <20 ng/mL conferred over twofold risk of disease activity
• Genetic predisposition to higher vitamin D levels was associated with:
  • Delayed age at MS onset
  • Higher probability of NEDA-3 status
• Mendelian randomisation confirmed causality between vitamin D and risk of disease activity

HCN Medical Memo
Although this study provides compelling evidence for the role of vitamin D in MS disease activity, further prospective studies are needed to determine the optimal vitamin D supplementation strategies and lifestyle interventions for MS patients. Clinicians should consider monitoring vitamin D levels in MS patients and discuss potential supplementation options, especially for those with levels below 20 ng/mL.

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