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JAMA Network
Gabapentin has been increasingly used as part of a multimodal analgesia regimen to reduce opioid use in perioperative pain management. In this cohort study of 237,872 adults aged 65 years or older, perioperative gabapentin users had significantly increased risk of delirium, new antipsychotic use, and pneumonia compared with nonusers after major surgery.
Anesthesiology October 3rd 2022
Annals of Internal Medicine
In a study involving 212 adults with symptomatic knee osteoarthritis, an unsupervised online yoga program delivered via prerecorded videos over 12 weeks netted improved physical function vs. the control group. At 12 weeks, knee stiffness, quality of life, and arthritis self-efficacy improved more with yoga than the control intervention. Benefits were not maintained at 24 weeks. Adverse events were minor.
Family Medicine/General Practice September 26th 2022
ACP Internist
57-year-old man, otherwise healthy 2 month history of recurrent abdominal pain with diarrhea A history of celiac disease that had been well controlled with a gluten-free diet 5-pound unintentional weight loss since the onset of symptoms Tissue IgA > 30x over nl What conditions would you consider in your evaluation?
Family Medicine/General Practice September 13th 2022
Medical Professionals Reference (MPR)
The recent United States Supreme Court ruling raises the bar for evidence that must be shown by the government in order to successfully prosecute doctors who prescribe excessive dosages of painkillers — a huge win for prescribers.
Anesthesiology September 12th 2022
Pharmacy Practice News
Sufentanil sublingual tablet 30 mcg (Dsuvia, AcelRx), an effective novel tablet formulation of the synthetic opioid sufentanil, has been given FDA approval for the management of severe acute pain in adult patients in licensed medically supervised healthcare settings. The medication is administered sublingually in a single-dose, prefilled applicator.
Clinical Pharmacology September 8th 2022
The knee arthritis meta-analysis reviewed 169 trials involving 21,163 patients, with the evidence demonstrating viscosupplementation is associated with a clinically irrelevant reduction in pain intensity and with an increased risk of serious adverse events compared with placebo. For the meniscus study, the commentary may sum it up best: “Multiple studies, including several with sham surgeries as a control have shown repeatedly over the previous 2 decades that surgery is not superior to physical therapy, yet the issue and use of surgery persist.”
Family Medicine/General Practice July 19th 2022