Epoch HealthCoffee Compound May Help Counteract Age-Related Muscle Loss

A Coffee-Derived Compound Linked to Enhanced Muscle Function in Aging Populations

Recent research highlights the potential role of trigonelline, a natural compound found in coffee, in combating sarcopenia—the age-related decline in muscle mass and strength. This study investigates the compound’s ability to enhance mitochondrial function and increase NAD+ levels, crucial for cell regeneration and protection, thus offering new avenues for dietary interventions to maintain muscle health in older adults.

Key Points:

• Muscle Health and Aging: Sarcopenia, characterized by the loss of muscle mass and strength, is exacerbated by reduced mitochondrial energy production and lower NAD+ levels in aging populations.
• Role of Trigonelline: Trigonelline, an alkaloid structurally related to vitamin B3 and found abundantly in coffee beans, has shown promise in reversing age-related declines in muscle function.
• Scientific Findings: A study published in Nature Metabolism revealed that high trigonelline levels in the blood of mice and worms correlate positively with muscle strength and functionality.
• Mechanism of Action: Trigonelline may boost muscle health by enhancing mitochondrial energy output and increasing NAD+ levels, crucial for cellular health and longevity.
• Dietary Sources of Trigonelline: Besides coffee, trigonelline is present in fenugreek seeds, barley, cantaloupe, corn, onions, peas, soybeans, tomatoes, fish, mussels, and crustaceans.
• Impact on Longevity: Supplementation with trigonelline in test animals not only improved muscle strength but also promoted longevity by activating energy production in cells.
• Clinical Implications: The findings suggest potential benefits of increasing trigonelline intake through diet or supplements to combat muscle loss in the elderly.

In a 2021 study, oral supplementation of 500 mg nicotinamide led to a significant increase in blood NAD+ after 12 hours and showed a trend of increase after 48 hours (P = 0.056), whereas 100 mg nicotinamide or water intake only did not change the NAD+ levels in the same subjects.

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