Promising Discovery: Existing Drugs Could Be Repurposed for First Treatment of Dementia-Linked Strokes
Clinical trials reveal the potential of two commonly used cardiac drugs, isosorbide mononitrate and cilostazol, to serve as novel treatment options for lacunar strokes, a leading cause of dementia.
Key Points:
- The study indicates that isosorbide mononitrate and cilostazol can be safely employed to improve outcomes after lacunar stroke.
- Used in combination, these drugs demonstrated heightened effectiveness, with potential to become a treatment for lacunar strokes within five years pending additional trials.
- Lacunar strokes, impacting 35,000 individuals in the UK annually, result from cerebral small vessel disease, a significant contributor to cognitive impairment and dementia.
- Currently, no specific effective treatments exist for these strokes, which can lead to issues with cognition, movement, and dementia.
- Participants who received both drugs reported approximately 20% less cognitive impairment, along with enhanced independence and quality of life.
- The drugs’ potential efficacy stems from their possible improvement of the inner lining of blood vessels, a suspected element in small vessel disease.
- The research team intends to verify these findings in a larger, four-year clinical trial and investigate the drugs’ effectiveness against other small vessel disease conditions.