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Journal of Clinical OncologyFirst-in-Human Phase I/IB Dose-Finding Study of Adagrasib (MRTX849) in Patients w. Advanced KRAS(G12C) Solid Tumors (KRYSTAL-1)

Adagrasib 600 mg twice a day was well tolerated and exhibited antitumor activity in patients with advanced solid tumors harboring the KRASG12C mutation.

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