Articles related to SOLID TUMORS
Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation
Explore the phase 1 study findings on Divarasib, a covalent KRAS G12C inhibitor, which has shown durable clinical responses with a favorable safety profile in patients with KRAS G12C-positive tumors.
Oncology, Medical August 28th 2023
Cancer Mortality After Low Dose Exposure to Ionising Radiation in Workers in France, the United Kingdom, and the United States (INWORKS): Cohort Study
This multinational study offers a comprehensive analysis of the association between protracted low dose exposure to ionising radiation and solid cancer mortality. Physicians and healthcare professionals may find the results significant in understanding and enhancing radiation protection, especially in contemporary medical settings.
Oncology, Medical August 21st 2023
Targeted Chemotherapy Pill Destroys All Solid Tumors in Early Testing
The targeted chemotherapy pill AOH1996, developed by the City of Hope, has shown promising results in preclinical research by targeting PCNA, a protein once thought to be too challenging for targeted therapy. Explore the potential of this novel approach as it advances to phase 1 clinical trials.
Oncology, Medical August 14th 2023
Roswell Park Oncologists and Scientists Bring Latest Research Findings to ASCO 2023
Roswell Park Comprehensive Cancer Center Shines at ASCO 2023 Roswell Park Comprehensive Cancer Center recently showcased a series of groundbreaking research studies at the American Society of Clinical Research (ASCO) 2023 meeting, highlighting their commitment to advancing cancer management and clinical trials. “This study has revealed differences in transcriptional metabolic profiles and other drivers of disease, as well as immune profiles, between younger and older CRC populations. This biology should be explored in the future, as new avenues for treatment in younger CRC populations.” Dr. Deepak Vadehra from the “Transcriptional metabolic profiling in young onset colorectal cancer (CRC) patients” study
Hematology/Oncology June 12th 2023
Partial Tumor Irradiation plus Pembrolizumab in Treating Large Advanced Solid Tumor Metastases
This study presents findings from a Phase I clinical trial examining the use of Stereotactic Body Radiotherapy (SBRT) combined with pembrolizumab (P) in treating advanced solid tumors, with a focus on the safety and effectiveness of partial tumor irradiation. The trial involved 97 patients, 47% of whom received at least one partial radiation treatment. The overall one-year local failure (LF) rate was 7.6%, and the results suggest an association between tumor response to SBRT+P and improved overall survival (OS), particularly for irradiated tumors. The trial also explored the role of biomarkers, finding that a high Radiomics Score (RS), based largely on CD8+ T cell levels, was linked to better LF, progression-free survival (PFS), and OS. Conversely, increased levels of circulating cytokine IL-8 were associated with worse PFS and OS. The study concluded that SBRT+P is safe for patients with large, advanced solid tumors and recommended further research to compare the effectiveness of complete versus partial tumor irradiation in the context of immunotherapy.
Oncology, Medical May 22nd 2023