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Monthly Prescribing Reference (MPR)Hypertension Journal Study: Evaluating ARBs vs. ACE Inhibitors Safety Outcomes

Findings: Primary outcomes included AMI, HF, stroke, and CVEs; 51 secondary and safety outcomes included angioedema, cough, syncope, and electrolyte abnormalities. ACE inhibitors were associated with a significantly increased risk of four secondary and safety outcomes compared with ARBs.
Design: Multinational cohort study; Patients: ~2.3M ACE, ~674K ARB