Psych Congress NetworkMethylphenidate Improved Driving Performance in Adults

A recent randomized controlled trial published in the Journal of Psychopharmacology investigated the effects of a 10 mg dose of methylphenidate on driving performance in adults. The study aimed to assess vehicle control and speed maintenance during prolonged, monotonous driving.

Key Clinical Considerations

• Sample Size: 25 healthy adults (mean age = 33.5 ± 7.8 years, 64% male).
• Methodology: Two 40-minute simulated highway drives, 1 week apart, with eye movements monitored.
• Primary Outcomes: Standard deviations of lateral position (SDLP), speed (SDS), and steering variability.
• Results: Significant reduction in lane weaving (SDLP mean difference = -1.33, p = 0.001) and speed variation (SDS mean difference = -0.56, p = 0.014).
• Ocular Metrics: Limited changes in gaze transition entropy (GTE) and stationary gaze entropy (SGE).

Clinical Practice Impact

• Patient Communication: Inform patients about the potential benefits of methylphenidate for improving driving performance.
• Practice Integration: Consider methylphenidate for patients with driving performance concerns, especially during prolonged driving.
• Risk Management: Monitor for any adverse effects and adjust dosage as necessary.
• Action Items: Further research needed to explore higher doses and long-term effects.

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