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Optometry and Vision Science (OVS)Risk Factors for Primary Angle-closure Glaucoma: A Systematic Review and Meta-analysis of 45 Studies

Unveiling the Factors Associated with Primary Angle-Closure Glaucoma: A Comprehensive Review

In a quest to better understand primary angle-closure glaucoma (PACG), a condition that can lead to vision loss, researchers have conducted a systematic review and meta-analysis. The study delves into the associated factors of PACG, shedding light on both ophthalmic anatomic factors and general morphological indicators.

Study Design

  • The study is a systematic review and meta-analysis of PACG-related factors.
  • The researchers searched electronic databases including PubMed, EMBASE, and Web of Science up to November 2021.
  • The study included 45 studies in the review.
  • The pooled risk estimates of continuous and categorical variables were calculated using weighted mean difference (WMD) and odds ratio (OR; 95% confidence intervals [CIs]).

According to the World Health Organization, glaucoma is the second leading cause of blindness worldwide.

Key Findings

  • Ophthalmic anatomic factors associated with PACG include intraocular pressure, anterior chamber depth, axial length, retinal nerve fiber layer, and spherical equivalent.
  • Lower body weight was identified as a significant general morphological indicator.
  • The presence of cataract and hyperlipidemia were significantly associated with PACG.
  • Increased level of triglyceride was associated with PACG.
  • An association between short-term antidepressant exposure and acute angle-closure glaucoma was observed.

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