Articles related to ADRENOCORTICAL CARCINOMA (ACC)
Case 38-2022: A 21-Year-Old Woman with Fatigue and Weight Gain
A mass measuring 4.8 cm by 5.0 cm by 3.9 cm was detected by transabdominal and transvaginal ultrasonography of the abdomen and pelvis. This mass was located along the posterior part of the right hepatic lobe. Following the clinic evaluation, there were two important questions to answer. Initially, was the adrenal tumor malignant or benign? Second, did the lesion secrete hormones?
Endocrinology, Diabetes, Metabolism January 3rd 2023
Expression and Clinical Significance of VISTA and PD-L1 in Adrenocortical Carcinoma (ACC)
The authors investigated expression of PD-L1 and V-domain Ig-containing suppressor of T cell activation (VISTA) in ACC and their associations with clinicopathological features and survival outcomes. They report that a higher VISTA expression intensity, a larger area, and a higher immunoscore were associated with increased risks of disease progression and overall mortality. However, PD-L1 expression in tumor cells or tumor-infiltrating immune cells was not associated with OS or DFS. The study points to the potential value of VISTA, in addition to PD-L1, as an immunotherapeutic target in ACC.
Oncology, Medical May 31st 2022