Articles related to CLINICAL TRIALS

In a multicenter trial, surgery, needle fasciotomy, and collagenase injections were evaluated for the treatment of treatment-naive Dupuytren contracture. The study demonstrated that, although the initial success rates were similar across treatments, surgical intervention yielded significantly higher success rates at the two-year follow-up, suggesting its potential long-term benefits over less invasive treatments.

LYN-005 represents a breakthrough in schizophrenia management, showing promise in maintaining therapeutic levels and symptom control with just once-weekly dosing.

In a recent phase 2 trial, frexalimab, targeting the CD40-CD40L pathway, demonstrated a notable reduction in new gadolinium-enhancing T1-weighted lesions in patients with relapsing multiple sclerosis.

In the KEYNOTE-564 trial, adjuvant pembrolizumab demonstrated a significant improvement in disease-free survival among patients with renal-cell carcinoma at high risk of recurrence after nephrectomy, offering a new direction in post-surgical treatment strategies.

Recent studies highlight the potential of cabozantinib plus atezolizumab in improving progression-free survival for mCRPC patients and confirm the benefits of high-dose radiotherapy in high-risk prostate cancer treatment, offering new insights into personalized care strategies.

The FDA’s approval of irinotecan liposome with oxaliplatin, fluorouracil, and leucovorin marks a pivotal advancement in first-line treatment options for metastatic pancreatic adenocarcinoma, showcasing a notable increase in overall and progression-free survival rates.