Early-Onset CLL | An ITP-Vaccine Link? | B-Cell ALL Clinical TrialMarch 09, 2021 | Oncology Hematology Early Intervention in Asymptomatic Chronic Lymphocytic Leukemia For the estimated 21,000 patients who will receive a diagnosis of chronic lymphocytic leukemia (CLL), 20% of them will have early-stage disease. Unfortunately, that 20% will not be offered treatment, as the current management of these patients follows a “watch-and-wait” paradigm. However, with the advent of better prognostic tools to identify patients at high risk, in addition to the recent approval of several novel oral agents with impressive efficacy, re-examining this approach now seems prudent. Read full article Allergy & Immunology Are Rare Cases of Immune Thrombocytopenia Linked to the COVID Vaccine? As of February 8, 2021, more than 31 million people in the U.S. had received at least one dose of the coronavirus vaccine, with 36 cases of immune thrombocytopenia (ITP) reported to the Vaccine Adverse Event Reporting System by the end of January. Is the onset of the condition related to the vaccines? The vaccines are considered safe overall, but what did the CDC and FDA have to say about it? Read full article Hematology Effect of Postreinduction Therapy Consolidation w. Blinatumomab vs. Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults w. First Relapse of B-Cell ALL In this Original Investigation from JAMA, the authors discuss the results of a randomized clinical trial that included 208 patients with high- and intermediate-risk first relapse of B-cell acute lymphoblastic leukemia (ALL). Did postreinduction treatment with blinatumomab compared with chemotherapy, followed by hematopoietic stem cell transplant, result in a statistically significant difference in disease-free survival? Read full article
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