HCN Oncology Year-in-Review: Hematology/OncologyDecember 21, 2021 | Oncology Hematology The Longitudinal Dynamics and Natural History of Clonal Hematopoiesis (CH) In this late-breaking abstract from the ASH Annual Meeting & Exhibition, the researches wanted to address the limited understanding of how and when CH develops, what factors govern its behavior, how it interacts with aging, and how these variables relate to malignant progression. Here are the results from analyzing 1,593 blood DNA samples from 385 elderly individuals, each sampled up to 5 times over approximately 13 years. Read full article Hematology Marrow or Peripheral Blood for Allogeneic Transplant: Are We Ignoring the Data? Despite peripheral blood making up 80% of all of hematopoietic cell transplants, there are similar rates of overall survival, disease-free survival, and transplant-related mortality when comparing marrow and peripheral blood as graft sources. Chronic graft-versus-host disease (GVHD) and cytokine release syndrome (CRS) are more significant in those who received peripheral blood, yet the standard of care hasn’t changed. Here, two doctors reflect on the debate. Read full article Hematology Clonal Hematopoiesis in Patients Receiving Chimeric Antigen Receptor (CAR) T-Cell Therapy Source: Blood AdvancesKey Points: In a cohort of 154 patients with NHL or MM receiving CAR T-cells, clonal hematopoiesis of indeterminate potential (CHIP) was present in 48%. Although associated with worse prognosis in these patients receiving autologous transplantation, no such association was seen in these patients receiving CAR T. Instead, the authors saw increased rates of complete response and cytokine release syndrome severity in the younger than 60 population. However, there was no difference in progression-free or overall survival, regardless of age. Design: Cohort review of 154 patients with NHL or MM receiving CAR T-cells Read full article Hematology Algorithmic Approach to Identify Patients With Germline Predisposition Syndromes (GPS), Including Those With Hematologic Malignancies Review Publication: Hematology AdvisorDesign: At the Annual Meeting of the Society of Hematologic Oncology, researchers presented a study identifying a higher percentage of patients with germline predisposition syndromes (GPS).Results: Following a review of medical records of patients diagnosed with GPS between 1994 and 2018, the investigators reported that the detection of GPS positively impacted medical care in 91% of cases, including proper selection of a bone marrow donor, selection of drug and conditioning regimens, and genetic counseling. Read full article Hematology A Landscape of Germ Line Mutations in a Cohort of Inherited Bone Marrow Failure (IBMF) Patients Bone marrow failure in children and young adults is often suspected to be inherited; however, in many cases, diagnosis remains uncertain. A new study involving 179 patients (from 173 families) found that implementing precision medicine at diagnosis can improve patient management, along with the use of family counseling. This study published in Blood expands the “portrait” of IBMF syndromes and explores some newly recognized disease entities. Read full article Hematology Management of Well-Differentiated Neuroendocrine Tumors Surgery still offers the best chance of cure for patients with neuroendocrine tumors (NETs). However, for locally advanced or metastatic well-differentiated tumors, medical therapy including theranostics, targeted therapies, and chemotherapy can all play a role. Clinical Advances in Hematology & Oncology reviews the diagnosis and management of these tumors. Read full article
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