Pediatric ALL | MM Outcomes & The Princess Bride | FLT3 Inhibitors in AMLJune 28, 2021 | Oncology Endocrinology, Diabetes, Metabolism Clinical Challenges: Pediatric ALL in Children With Obesity Pediatric B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy seen in children and adolescents and young adults (AYAs). This article highlights two recent studies that provide novel evidence of the association between obesity and increased risk of high-risk B-ALL and the effectiveness of a non-pharmacologic intervention for reducing minimal residual disease (MRD) risk. Read full article Family Medicine/General Practice What “The Princess Bride” Teaches Us About Outcomes in Multiple Myeloma “It’s inconceivable!” This famous line and exchange from the 1987 classic film The Princess Bride, along with the fates of the characters Vizzini and Inigo Montoya, provide the fulcrum for this Journal of Clinical Oncology (JCO) editorial, which highlights the phase III TOURMALINE-MM1 trial and its seemingly “negative” findings in multiple myeloma (MM). Are we considering the inconceivable? Do we know what the word even means? Read full article Hematology FLT3 Inhibitors in Acute Myeloid Leukemia: Increasing Options In this Clinical Advances in Hematology & Oncology Q&A with Dr. Tapan M. Kadia, an associate professor at the MD Anderson Cancer Center, the current treatments for acute myeloid leukemia (AML) are discussed, with a specific focus on the targeted FLT3 approach, the role of the gene in AML, the differences among the approved FLT3 inhibitors, and why newer FLT3 inhibitors are needed. Read full article
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