A phase II study of durvalumab alone or combined with the anti-CD73 monoclonal antibody oleclumab or anti-NKG2A monoclonal antibody monalizumab as consolidation therapy in patients with unresectable stage III NSCLC and no progression after concurrent chemoradiotherapy. With a median follow-up of 11.5 months, both combinations increased ORR and prolonged PFS versus durvalumab alone. Safety was similar across arms with no new or significant safety signals identified with either combination.

Researchers explain why the Omicron variant of COVID-19 is so contagious and spreads so rapidly in the general population.

As use of gabapentin in the United States has been steadily increasing in recent years, researchers from the CDC have found that, among the 62,652 overdose deaths that occurred between 2019 and 2020, 58,362 of these cases had documented toxicology results.

Mounjaro (tirzepatide) is a first-in-class, once-weekly, dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that integrates the actions of both incretins into a single molecule. It enhances first- and second-phase insulin secretion, and reduces glucagon levels, both in a glucose-dependent manner. The FDA approval of Mounjaro as an adjunct therapy to diet and exercise for adults with type 2 diabetes was based on clinical trials where treatment with Mounjaro resulted in statistically significant reduction in both A1c and weight vs. semaglutide, insulin degludec, and insulin glargine.

The Infectious Diseases Society of America (IDSA) has issued guidance on managing drug interactions with nirmatrelvir/ritonavir (Paxlovid). Specifically, the IDSA recommends clinicians take six steps to minimize the risk of drug interactions for patients with COVID-19 who are eligible for nirmatrelvir/ritonavir.

Here are some highly rated but lesser-known restaurants the locals like: Less than a mile from McCormick Place is the Chinese fusion restaurant Go 4 Food. Try the Sweet and Sour Chinese-Style Ribs, the succulent Walnut Shrimp, or the spicy Chili Fusion Dungeness Crab with some Millionaire-Style Fried Rice A 10-minute drive down S. Riverside Drive yields Norman’s Bistro, featuring American creole cuisine If you are up to the 20-minute ride to Lincoln Park, the locals say Toro Sushi is the spot for sushi in Chicago Within 15 minutes of the convention center are these top-rated choices: Chicago Firehouse (American) Avec Restaurant (Mediterranean) Monteverde Restaurant & Pastificio (Italian) And if you have time before dinner, this unique museum is in the same area, just off the Magnificent Mile.