Articles related to CLINICAL STUDY

In a randomized controlled trial at three US hospitals over six months in 2021, the researchers randomized 30 attendings to prioritize seeing patients who were expected to be discharged that day before seeing other patients. Marisha Burden, MD, FACP, a professor of medicine and division head of hospital medicine at the University of Colorado School of Medicine in Aurora, and Angela Keniston, MSPH, an assistant professor and director of data and analytics for the division of hospital medicine at the University of Colorado School of Medicine, discuss the study’s findings.

In a study of nearly 100,000 individuals aged 30 to 95 without any prior evidence of CVD, decline in peak metabolic equivalent of task score (METS) of greater than 1.0 was inversely proportionate to changes in mortality risk. METS were determined using symptom-limited exercise treadmill tests.

In this study, 800 patients admitted to ICU for severe CAP were andomized to 200mg IV hydrocortisone daily for 4 to 8 days or to placebo. By day 28, mortality rate was 6.2% versus 11.9% for the steroid and placebo groups, respectively. Rates for intubation and vasopressors were both approximately 40% lower in the test group as well.

Originally published in JAMA Psychiatry, a broad-based study shows nearly 7% of OUD patients are adding buprenorphine to urine sample to fake treatment adherence. Buprenorphine spiking suggests to the physician that the treatment plan is not working—especially in patients continuing illicit drug use.

The authors present the findings of a large retrospective cohort study that used national data from the SEER-Medicare-linked database to better understand the relationship between antibiotics and PDAC survival. They discovered that perichemotherapy antibiotics were associated with improved survival in patients treated with first-line gemcitabine but not fluorouracil, implying that perichemotherapy antibiotic treatment may have a role in patients with metastatic PDAC receiving gemcitabine. Prospective studies on the effect of perichemotherapy antibiotics with high pancreatic penetration and gram-negative coverage on survival in diverse populations of patients with metastatic PDAC treated with gemcitabine are recommended.

Aripiprazole supplementation of existing antidepressants in older adults with treatment-resistant depression significantly improved wellbeing over 10 weeks compared to switching to bupropion, and it was also associated with a numerically higher incidence of remission. Changes in wellbeing and the occurrence of remission with lithium augmentation or a switch to nortriptyline were comparable among patients in whom augmentation or a switch to bupropion failed.