Articles related to EPILEPSY/SEIZURES

Based on previously found and published population pharmacokinetic models, Monte Carlo simulation was used to investigate corrective dosing regimens. The delayed time, predetermined dose interval, and half-life of the antiseizure medicine were strongly linked with the suggested treatment regimens. Additionally, there were differences between the best treatment plans for adult and pediatric patients. The treatment plans may also be influenced by renal function and concurrent medications that affect the antiseizure drug’s clearance. A user-defined module with all parameters that could be configured flexibly by the user was also established in order to provide tailored remedial regimens for the delayed or missing dose. Both of these tools are web-based dashboards.

AI has exploded onto the scene in society, business, science, and medicine. At the same time, there are now decades of data from brain surgeries for DRE to train the programs. This confluence suggests that applications for precision epilepsy surgery may be here soon.

It is generally agreed that sudden unexpected death in epilepsy could be averted if the patient could be rapidly ventilated following the seizure. Diaphragmatic pacing is a surgical intervention used in spinal cord injury, sleep apnea, and similar causes of ventilatory failure. In this mouse model, all of the animals receiving the intervention survived, compared with death in most of the animals in the control arm of the study.

A chart review of 81 million individuals yielded two matched groups of more than 150,000 patients each: one with COVID and the other with influenza. In these populations, the risk of seizures and epilepsy was higher in the COVID group. The HR of epilepsy after COVID compared with influenza was highest in individuals who were not hospitalized and in those under the age of 16.

In this study of 243 adolescent and adult patients, addition of Modified Atkins Diet (MAD) to standard drug therapy netted seizure reduction of >50% in 26% of patients in the intervention arm versus 2.5% in the control group.

Overall, studies on sudden unexpected death in epilepsy (SUDEP) counseling emphasize the importance of patient and family education and agree on its content and process. Future research should look into how it affects epilepsy management and the psychosocial well-being of adults and children with epilepsy and their caregivers from various cultural and ethnic backgrounds, as well as SUDEP rates. In this regard, the impact of newer technologies and health-care models should be assessed. Although the scientific community is hard at work elucidating the pathophysiology and prevention strategy of this dreaded occurrence, such longitudinal studies have the potential to inform both practice and policy, as well as act as a catalyst in bridging the currently existing gap between family-desired and clinician-provided counseling.