Articles related to LUPUS

Chilblain lupus erythematosus can present with atypical features, such as nasal involvement, in addition to the more common acral lesions.

Researchers have identified insufficient activation of the aryl hydrocarbon receptor (AHR) pathway as a key driver in lupus pathogenesis, offering a new target for therapeutic intervention.

Researchers discovered that inhibiting the activity of the fumarate hydratase enzyme in macrophages (a type of immune cell that plays a key role in inflammatory disorders) increased the cells’ production of interferon-beta. They also discovered that lupus patients’ macrophages have abnormally low levels of fumarate hydratase. These findings suggest that dysregulation of this enzyme may be a factor in the development of lupus, and that fumarate hydratase could be a potential therapeutic target.

On exam, this 19-year-old woman has malar rash characterized by pink-violet papules and plaques with no other physical finding. ANA is positive and urinalysis is remarkable for 3+ blood and protein. What test is the most appropriate next step?

Among more than 3,000 patients taking hydroxychloroquine, overall cumulative incidence for developing retinopathy were 2.5% and 8.6% at 10 and 15 years respectively. Incidence was strongly dose-related and most cases were mild.