Articles related to RESEARCH & CLINICAL TRIALS

A study of 107 pregnant or postpartum persons with unusual prenatal cfDNA screening results found that specific genomic patterns—particularly the presence of copy-number gains and losses across three or more chromosomes—were associated with occult cancer in 95.9% of cases, suggesting potential new criteria for risk stratification.

Post-trial analysis reveals a 13% relative reduction in cardiovascular death and kidney disease progression risk, though this benefit primarily manifests in the first 12 months after treatment discontinuation.

A multicenter trial of 7,062 post-MI patients found that colchicine therapy, despite reducing C-reactive protein levels by 1.28 mg/L, did not significantly impact the composite outcome of cardiovascular death, recurrent MI, stroke, or unplanned revascularization over 3 years of follow-up.

In this randomized trial of 1,010 patients with stable DES undergoing noncardiac surgery, perioperative aspirin continuation showed no significant reduction in major adverse cardiac events compared to complete antiplatelet cessation.

Bloodstream infections cause 2.9 million deaths worldwide annually, with over 600,000 cases and 90,000 related deaths occurring in North America alone.

A multicenter trial reports that adding middle meningeal artery embolization to surgical evacuation reduced reoperation rates from 11.3% to 4.1% in subdural hematoma patients, though further safety evaluation is needed.